Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 11 hits in this display
IC50: 133nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Kd: 2.10E+3nMAssay Description:Binding affinity to human wild-type partial length VPS34 (S282 to H879 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: 4.10E+3nMAssay Description:Binding affinity to human wild-type partial length PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: 610nMAssay Description:Binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: 8.70E+3nMAssay Description:Binding affinity to human wild-type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: 6.20E+3nMAssay Description:Binding affinity to human wild-type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: 34nMAssay Description:Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Kd: >3.00E+4nMAssay Description:Binding affinity to wild-type human full-length PI4Kbeta (M1 to M828 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair