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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 30 hits in this display   

TargetNischarin(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  4nMAssay Description:Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  35nMAssay Description:Binding affinity at human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  59nMAssay Description:Binding affinity at human alpha2A ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  99nMAssay Description:Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Universita Degli Studi Di Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  525nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Universita Degli Studi Di Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  525nMAssay Description:Binding affinity at human alpha2B ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  550nMAssay Description:Binding affinity at human alpha2C ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  550nMAssay Description:Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi:  1.74E+3nMAssay Description:Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataIC50:  59nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]-clonidine binding (0.4 nM) to rat isolated brain mem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataIC50:  890nMAssay Description:Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.2 nM) to rat isolated brain membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  63nMAssay Description:Potency against cloned human alpha 1B adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  126nMAssay Description:Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  13nMAssay Description:In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human alpha2C ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Universita Degli Studi Di Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha2B ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  126nMAssay Description:Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  13nMAssay Description:Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  126nMAssay Description:Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  63nMAssay Description:Activation of human alpha-1B adrenergic receptors expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  13nMAssay Description:Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Universita Degli Studi Di Camerino

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  126nMAssay Description:In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as fu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  63nMAssay Description:In vitro activation of human Alpha-1B receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as function...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  13nMAssay Description:Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PL...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50027060(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Affinity DataEC50:  63nMAssay Description:Activation of recombinant human adrenergic, alpha-1B receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled P...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed