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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Serine-protein kinase ATM
(Homo sapiens (Human))
Charles River
Curated by
ChEMBL
Ligand
BDBM50571469
(CHEMBL4852763 | US11685734, Example 270)
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Affinity Data
Ki: 1nM
Assay Description:
Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Phosphatidylinositol 3-kinase catalytic subunit type 3
(Homo sapiens (Human))
Charles River
Curated by
ChEMBL
Ligand
BDBM50571469
(CHEMBL4852763 | US11685734, Example 270)
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Affinity Data
Ki: 840nM
Assay Description:
Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine-protein kinase ATM
(Homo sapiens (Human))
Charles River
Curated by
ChEMBL
Ligand
BDBM50571469
(CHEMBL4852763 | US11685734, Example 270)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.40nM
Assay Description:
ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Serine-protein kinase ATM
(Homo sapiens (Human))
Charles River
Curated by
ChEMBL
Ligand
BDBM50571469
(CHEMBL4852763 | US11685734, Example 270)
Copy SMILES
Copy InChI
Affinity Data
IC50: 820nM
Assay Description:
Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI