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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetSerine-protein kinase ATM(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50:  70nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550673(CHEMBL4745255)
Affinity DataIC50:  82nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cells assessed as reduction in p53 Ser15 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed