Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  53.9nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  53.9nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  171nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  171nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.65E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50:  1.65E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280342(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-p...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent

Copy BDB DOI