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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 40 hits in this display   

TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2 adrenergic receptor in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  0.0150nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
In DepthDetails PubMed
TargetAlpha-2B adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  2.00nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  2.04nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  2.51nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  3.39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  5nMAssay Description:in vitro alpha-2A adrenergic receptor binding assay from rats ,using RX 821002 as the displaceable ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  5nMAssay Description:Tested for Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  13.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  15.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  15.8nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2B adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  19.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  25nMAssay Description:Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]rauwolscine from Alpha-2 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]RX 821002 from human adrenergic alpha-2c receptor expressed in CHO cells in presence of GppNHp/NaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  33.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1D adrenergic receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  95.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(wild yak)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1B adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  316nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50241196((R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  1.11E+3nMAssay Description:Alpha-1 adrenergic receptor binding affinity in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of [3H]-prazosin from Alpha-1 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataIC50:  2.90E+3nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataIC50:  3.40E+3nMAssay Description:Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataEC50:  281nMAssay Description:50% Molar effective concentration afainst Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50085683((+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole | 4...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed