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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
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Target
Non-lysosomal glucosylceramidase
(Human)
University of Napoli Federico Ii
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Non-lysosomal glucosylceramidase
(Human)
University of Napoli Federico Ii
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Ceramide glucosyltransferase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Lysosomal acid glucosylceramidase
(Human)
TBA
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Sucrase-isomaltase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of sucrase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Lysosomal alpha-glucosidase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of maltase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Beta-galactosidase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50335387
(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
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Affinity Data
IC50: 3.50E+5nM
Assay Description:
Inhibition of lactase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI