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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
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Target
Non-lysosomal glucosylceramidase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 250nM
Assay Description:
Inhibition of GBA2 (unknown origin)
More data for this Ligand-Target Pair
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Target
Non-lysosomal glucosylceramidase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 250nM
Assay Description:
Inhibition of GBA2 by HPLC
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Target Info
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Target
Non-lysosomal glucosylceramidase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay
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Target
Ceramide glucosyltransferase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide
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Target
Ceramide glucosyltransferase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of GCS by cell-based assay
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Target Info
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Target
Ceramide glucosyltransferase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 2.00E+4nM
Assay Description:
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
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Target
Glycogen debranching enzyme
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of glycogen glycogen de-branching enzyme by HPLC
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Target
Lactase/phlorizin hydrolase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 1.00E+6nM
Assay Description:
Inhibition of lactase by HPLC
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Target
Maltase-glucoamylase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of maltase by HPLC
More data for this Ligand-Target Pair
Target Info
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Target
Lysosomal acid glucosylceramidase
(Human)
TBA
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Sucrase-isomaltase, intestinal
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: 1.00E+6nM
Assay Description:
Inhibition of sucrase by HPLC
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Lysosomal alpha-glucosidase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of maltase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
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Target
Beta-galactosidase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of lactase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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CHEMBL
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Target
Sucrase-isomaltase
(Mouse)
TBA
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of sucrase in mouse intestinal input by glucose release assay
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
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CHEMBL
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Target
Lysosomal alpha-glucosidase
(Human)
Leiden University
Curated by
ChEMBL
Ligand
BDBM50312526
(CHEMBL1076754 | N-Butyl-L-ido-1-deoxynojirimycin)
Copy SMILES
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of lysosomal alpha-glucosidase by HPLC
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
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KEGG
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