Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetLIM domain kinase 1(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL

LigandBDBM50072671(CHEMBL3410055)Copy SMILESCopy InChI

Affinity DataIC50:  19nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetLIM domain kinase 1(Rattus norvegicus)
Translational Research Institute

Curated by ChEMBL

LigandBDBM50072671(CHEMBL3410055)Copy SMILESCopy InChI

Affinity DataIC50:  320nMAssay Description:Inhibition of Limk1 in rat A7r5 cells assessed as reduction in cofilin phosphorylation by Western blot methodMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL

LigandBDBM50072671(CHEMBL3410055)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI