Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 16 hits in this display   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50:  7nMAssay Description:Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50:  8nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of ALK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of DDR1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MET (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of RON (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of AXL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK-2 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK-1 (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of InsR (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FAK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ABL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50443366(CHEMBL3086065)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of BRK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed