Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 129 hits in this display
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 220nMAssay Description:Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.00E+3nMAssay Description:Inhibition of amyloid beta 40 (unknown origin) assessed as disaggregation of fibrillar amyloid beta 40 incubated for 3 days by ELISA assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.07E+3nMAssay Description:Inhibition of porcine kidney DAAO using D-serine as substrate by Amplex red and horseradish peroxidase fluorescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.50E+3nMAssay Description:Inhibition of self-induced amyloid beta 40 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysisMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 2.00E+3nMAssay Description:Inhibition of bovine seminal vesicle COX uing [1-14C]PGH2 as substrate by TLC/liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 3.10E+3nMAssay Description:Inhibition of self-induced amyloid beta 42 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysisMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 3.85E+3nMAssay Description:Inhibition of human biotinylated amyloid beta (1 to 42) oligomerization assessed as decrease in oligomer abundance measured after 1 hr by ELISAMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 7.75E+3nMAssay Description:Inhibition of Trypanosoma brucei rhodesain using Cbz-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 8.27E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs by Thioflavin T based fluorometric assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 9.00E+3nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) aggregation after 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
Sortase(Streptococcus mutans)Indian Institute of Technology Delhi
Curated by ChEMBL
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.13E+4nMAssay Description:Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 10 hrs by thioflavin T based fluorometric assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.50E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation after 24 hrs by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.63E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation incubated for 48 hrs by thioflavin-T fluorescence methodMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.80E+4nMAssay Description:Inhibition of human recombinant GSK3-beta using prephosphorylated polypeptide as substrate incubated for 30 mins by Glo-type luminescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.87E+4nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 24 hrs by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 2.25E+4nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation after 24 hrs by ThT-based fluorometric methodMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
IC50: 1.87E+5nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
Kd: 3.79E+5nMAssay Description:Binding affinity to recombinant human MD2 (17 to 160 residues) expressed in Escherichia coli BL21(DE3) cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
Kd: >1.00E+3nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
EC50: 2.10E+4nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
Kd: >1.00E+4nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
BDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
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