Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 261 hits in this display
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.0580nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.25nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.414nMAssay Description:Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic substrate in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.421nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.900nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.900nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 0.950nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: <1nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) using TK as substrate incubated for 1 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: <1nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK as substrate incubated for 1 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.20nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.20nMAssay Description:Inhibition of wild type EGFR L858R mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.20nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using biotinylated TK peptide as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.80nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.80nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.90nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expressi...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 2nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Bac...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 2.10nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 2.40nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 3nMAssay Description:The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 3.40nMAssay Description:Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 3.40nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 4.60nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 8nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 16nMAssay Description:Inhibition of wildtype EGFR (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 21nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 25nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 27nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 35nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 38nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 73.8nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 90nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Bacu...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 109nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 110nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 128nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 141nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 152nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in ...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 165nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 225nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 230nMAssay Description:The inhibition activity and the selectivity of the compounds against mutant EGFR and WT EGFR were assessed by using WT EGFR cell line A-431 (American...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 260nMAssay Description:Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 300nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 480nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 480nMAssay Description:Inhibition of EGF-stimulated wild type EGFR phosphorylation in human LoVo cells incubated for 2 hrs followed by EGF stimulation for 10 mins by ELISAMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 626nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 730nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 769nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 800nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 950nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: >1.00E+3nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Histone deacetylase(Homo sapiens (Human))Shandong First Medical University & Shandong Academy Of Medical Sciences
Curated by ChEMBL
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.08E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.12E+3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.17E+3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant (696-end residues) by fluorescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.23E+3nMAssay Description:Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 3.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in baculovirus expression system by fluorescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.50E+4nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
IC50: 1.70E+4nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 2.37E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured afte...More data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 667nMAssay Description:Inhibition of wild-type EGFR in human A431 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 43nMAssay Description:Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 1.75E+3nMAssay Description:Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 66nMAssay Description:Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 6nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 3.21E+3nMAssay Description:Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay in presence of ceritinibMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
EC50: 190nMAssay Description:Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs in presence of ceritinib by MTS assayMore data for this Ligand-Target Pair
BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
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