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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
24
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 1.10nM
Assay Description:
Inhibition of [125I]- NCQ 298 binding to D2 receptor of rat striatal tissue
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 1.20nM
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Target
D(2) dopamine receptor
(Mus musculus (Mouse))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 1.30nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 2.20nM
Assay Description:
Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 10nM
Assay Description:
In vitro binding affinity on D3 receptor is inhibition of binding of [125I]- NCQ 298 to Sf9 cells infected with recombinant baculovirus
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
University of Pennsylvania
Curated by
PDSP K
i
Database
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 10.4nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 11.9nM
Assay Description:
Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes
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Target
5-hydroxytryptamine receptor 4
(MOUSE)
Cnrs Upr 9023
Curated by
PDSP K
i
Database
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 53.7nM
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 89nM
Assay Description:
In vitro binding affinity on 5-hydroxytryptamine 2 receptor is inhibition of binding of [125I]- I-LSD to P11 cells
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 104nM
Assay Description:
Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 104nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 170nM
Assay Description:
Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 600nM
Assay Description:
In vitro binding affinity on alpha-2 receptor is inhibition of binding of [3H]- rauwolscine to rat cortex
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Target
D(1A) dopamine receptor
(Mus musculus (Mouse))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 820nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
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Target
D(1A) dopamine receptor
(BOVINE)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
Ki: 6.00E+3nM
Assay Description:
Displacement of [3H]-SCH-23,390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
University Of Pennsylvania
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
IC50: 603nM
Assay Description:
Inhibition of human ERG
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Target
Acetylcholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50132693
(4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...)
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Affinity Data
IC50: 890nM
Assay Description:
Inhibition of AChE
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