Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 32 hits in this display
IC50: 8nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
BDBM304727(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
BDBM304727(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
BDBM304721(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
IC50: 20nMAssay Description:Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
BDBM304748(BDBM304749 | US10144731, Example 34a)
IC50: 24nMAssay Description:Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
BDBM304728(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
IC50: 42nMAssay Description:Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
BDBM304748(BDBM304749 | US10144731, Example 34a)
IC50: 55nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
BDBM304748(BDBM304749 | US10144731, Example 34a)
IC50: 55nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
BDBM304728(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
IC50: 55nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
BDBM304721(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
IC50: 55nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
BDBM304727(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 11nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
BDBM304728(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 760nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
BDBM304748(BDBM304749 | US10144731, Example 34a)
EC50: 83nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
BDBM304721(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 30nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
BDBM304748(BDBM304749 | US10144731, Example 34a)
BDBM304748(BDBM304749 | US10144731, Example 34a)
EC50: 550nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
BDBM304728(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 5.50E+3nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
BDBM304727(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 55nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
BDBM304721(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
EC50: 550nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair