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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
NACHT, LRR and PYD domains-containing protein 3
(Mus musculus)
Shandong University
Curated by
ChEMBL
Ligand
BDBM50505850
(Dapansutrile | OLT-1177 | OLT1177)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 30 mins follow...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC cid
PC sid
In Depth
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Article
PubMed
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Target
NACHT, LRR and PYD domains-containing protein 3
(Mus musculus)
Shandong University
Curated by
ChEMBL
Ligand
BDBM50505850
(Dapansutrile | OLT-1177 | OLT1177)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1nM
Assay Description:
Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
PubMed
Copy BDB DOI
Target
NACHT, LRR and PYD domains-containing protein 3
(Mus musculus)
Shandong University
Curated by
ChEMBL
Ligand
BDBM50505850
(Dapansutrile | OLT-1177 | OLT1177)
Copy SMILES
Copy InChI
Affinity Data
IC50: 100nM
Assay Description:
Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI