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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  15nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  15nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  31nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  31nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  50nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  50nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  71nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  71nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  179nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSerine/threonine-protein kinase B-raf [409-765](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  179nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetDiscoidin domain-containing receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  181nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetDiscoidin domain-containing receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185590(US9156852, 105 | USRE47451, Example 105)
Affinity DataIC50:  181nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
In DepthDetails US Patent