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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
68
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Target
Thymidine kinase, cytosolic
(Homo sapiens (Human))
Michigan Cancer Foundation
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.90E+3nM
Assay Description:
Inhibitory affect against rabbit thymus thymidine kinase and represented as molt/4F kinase.
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Target
Thymidine kinase, cytosolic
(Homo sapiens (Human))
Michigan Cancer Foundation
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 7.00E+3nM
Assay Description:
Inhibitory affect against rabbit thymus thymidine kinase
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysis
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm)
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis
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Target
UDP-glucuronosyltransferase 2B7
(Homo sapiens (Human))
University Of Rhode Island
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 1.50E+5nM
Assay Description:
Uncompetitive substrate inhibition of UGT2B7 in diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide form...
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Target
UDP-glucuronosyltransferase 2B7
(Homo sapiens (Human))
University Of Rhode Island
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 1.50E+5nM
Assay Description:
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide ...
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Target
UDP-glucuronosyltransferase 2B7
(Homo sapiens (Human))
University Of Rhode Island
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.00E+5nM
Assay Description:
Uncompetitive substrate inhibition of UGT2B7 in diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide forma...
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Target
UDP-glucuronosyltransferase 2B7
(Homo sapiens (Human))
University Of Rhode Island
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 2.00E+5nM
Assay Description:
Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide f...
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Target
Thymidine kinase
(Staphylococcus aureus)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Ki: 9.44E+5nM
Assay Description:
Inhibition of Staphylococcus aureus CCM 885 recombinant thymidine kinase
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 3.10nM
Assay Description:
Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS cells
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Target
Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1)
Tosoh
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 6nM
Assay Description:
Inhibitory effect of the compound on HIV-1 RT activity using template primer,poly (rA)-oligo (dT)
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 10nM
Assay Description:
Tested for the inhibition of the compound towards HIV-reverse transcriptase
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 11nM
Assay Description:
antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatant
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 12.7nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 30nM
Assay Description:
Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 40nM
Assay Description:
Concentration required to inhibit HIV reverse transcriptase
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Copy SMILES
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of HIV1 reverse transcriptase
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition on HIV1 reverse transcriptase p66/p51
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: <100nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cells
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...
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Target
Thymidine kinase, cytosolic
(Homo sapiens (Human))
Michigan Cancer Foundation
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of human TK1 by liquid scintillation counting
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Nci-Frederick
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 3.60E+3nM
Assay Description:
Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs b...
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Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 4.54E+3nM
Assay Description:
Inhibition of HIV1 reverse transcriptase
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Target
Thymidine kinase
(Ureaplasma parvum)
Swedish University Agricultural Sciences
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 1.25E+4nM
Assay Description:
Inhibition of Ureaplasma parvum thymidine kinase by liquid scintillation counting
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 1.82E+4nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA plate reader analysis
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Target
DNA polymerase beta
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of DNA polymerase beta
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 2.01E+4nM
Assay Description:
Inhibition of HIV1 reverse transcriptase using DIG-labeled dNTPs as substrate after 1 hr by ELISA
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 2.05E+4nM
Assay Description:
Inhibition of HIV1 reverse transcriptase incubated for 1 hr by colorimetric assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: 2.14E+4nM
Assay Description:
Inhibition of HIV1 reverse transcriptase activity after 1 hr by ELISA
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Target
Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1)
Tosoh
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibitory effect of the compound on HIV-1 RT activity using template primer,poly (rA)-oligo (dT)
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Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of recombinant HIV-1 reverse transcriptase
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase.
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Copy BDB DOI
Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Compound was evaluated for enzymatic inhibitory activity against recombinant HIV reverse transcriptase
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Copy BDB DOI
Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay system
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
Protein kinase C epsilon type
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.50E+5nM
Assay Description:
Inhibition of PKC epsilon
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Protein kinase C beta type
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
IC50: >1.50E+5nM
Assay Description:
Inhibition of PKC beta2
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Target
Envelope glycoprotein gp160
(Human immunodeficiency virus type 1 group M subtyp...)
Chimerix
US Patent
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant.
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Target
Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1)
Tosoh
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 126nM
Assay Description:
Inhibitory activity against HIV-1 IIIB in CEM-SS infected cells(Experiment 1)
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Target
Albumin
(Homo sapiens (Human))
Mercer University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
Kd: 4.40E+4nM
Assay Description:
Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysis
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Target
C-X-C chemokine receptor type 4
(Homo sapiens (Human))
Kyoto University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 7.90nM
Assay Description:
Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assay
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Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 10nM
Assay Description:
Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay.
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 2.49E+4nM
Assay Description:
Tested in vitro against HIV-1 MDR using MAGI assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 38nM
Assay Description:
Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 8nM
Assay Description:
Antiviral activity against HIV1 IRLL98 in MT4 cells by MTT assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Antiviral activity against HIV1 K103N mutant in MT4 cells by MTT assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Antiviral activity against HIV1 Y188L mutant in MT4 cells by MTT assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controls
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Target
C-X-C chemokine receptor type 4
(Homo sapiens (Human))
Kyoto University
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 48nM
Assay Description:
Inhibition of HIV-induced cytopathogenicity in MT-4 cell
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 3nM
Assay Description:
Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cells
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Wayne State University School of Medicine
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 2nM
Assay Description:
Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells.
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Target
HIV-1 protease
(Human immunodeficiency virus)
The Regents of The University of California
US Patent
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 7nM
Assay Description:
Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 8.90nM
Assay Description:
Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cy...
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 6.60nM
Assay Description:
Inhibition of HIV-1 reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect mea...
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Target Info
PDB
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UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 7nM
Assay Description:
Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT as...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 17nM
Assay Description:
Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cy...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Wuhan University of Technology
Curated by
ChEMBL
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 5.40nM
Assay Description:
Binding affinity to HIV1 reverse transcriptase assessed as compound incorporation into DNA by primer extension assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Gag-Pol polyprotein
(HIV-1)
Yunnan University
US Patent
Ligand
BDBM50002692
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
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Affinity Data
EC50: 49nM
Assay Description:
C8166 cells infected with HIV-1 were used for determining the anti-HIV biological activity at the cellular level. The specific method was described b...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
US Patent
Copy BDB DOI
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