Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 22 hits in this display   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  1.20nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  13nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  18nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  19nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  19nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  36nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  41nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  44nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  44nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  98nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  98nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  114nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  120nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  120nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  125nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  125nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  146nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  159nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  159nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  159nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent