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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
468
hits in this display
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.0160nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.140nM
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
Assay Description:
Binding affinity to 5HT2A receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor.
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.160nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in rat brain
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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ChEBI
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MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.170nM
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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MCE
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.170nM
Assay Description:
Antagonist activity at 5HT2A receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.180nM
Assay Description:
Displacement of [3H] ketanserin from 5-HT2A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting ana...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.180nM
Assay Description:
Displacement of [3H]-ketanserine from serotonin 5-HT2A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation countin...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
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MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.190nM
Assay Description:
Binding affinity to 5-HT2A receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
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Ligand Info
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ChEBI
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.190nM
Assay Description:
Displacement of [3H]ketanserin from rat cerebral cortex 5HT2A receptor measured after 15 mins by liquid scintillation counting method
More data for this Ligand-Target Pair
Target Info
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ChEBI
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In Depth
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
In vitro ability to displace [3H]ketanserin binding from 5-hydroxytryptamine 2A receptor in rat striatal membrane.
More data for this Ligand-Target Pair
Target Info
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ChEBI
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PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
ChEBI
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PubMed
Copy BDB DOI
Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
The binding affinity was measured on 5-hydroxytryptamine 2 receptor in rat brain tissue
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Affinity for 5-hydroxytryptamine 2 receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.210nM
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.25nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.25nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
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In Depth
Details
PubMed
Copy BDB DOI
Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.25nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.260nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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ChEBI
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.290nM
Assay Description:
Binding affinity to human cloned 5HT2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Ligand Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Ligand Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.300nM
Assay Description:
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.310nM
Assay Description:
Displacement of [3H]ketanserine from 5-HT2A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.370nM
Assay Description:
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cell membranes measured after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 0.390nM
Assay Description:
Binding affinity for human 5-hydroxytryptamine 2A receptor
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.390nM
Assay Description:
Binding affinity to 5HT2A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.390nM
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.400nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
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Target
5-hydroxytryptamine receptor 7
(GUINEA PIG)
Monash University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 0.400nM
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.420nM
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.430nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.440nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.440nM
Assay Description:
Binding affinity towards human D2 dopamine receptor.
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.440nM
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Target
Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.5nM
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.5nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.5nM
Assay Description:
Displacement of [3H]-ketanserin from human 5-HT2AR expressed in CHO-K1 cell membranes after 1.5 hrs by microbeta counting method
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.501nM
Assay Description:
Displacement of [3H]ketanserin from human cloned 5HT2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.501nM
Assay Description:
Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.501nM
Assay Description:
Displacement of [3H]ketanserin human cloned serotonin 5HT2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.520nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
Assay Description:
Displacement of [3H]-raclopride from human D2LR expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.690nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.700nM
Assay Description:
Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]-ketanserin binding to rat cortex using unlabeled mianserin...
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.700nM
Assay Description:
Binding affinity to adrenergic alpha1 receptor (unknown origin)
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.810nM
Assay Description:
Inhibition of [125I]-R91150 binding to human 5-hydroxytryptamine 2A receptor
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
D(2) dopamine receptor
(GUINEA PIG)
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.830nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.880nM
Assay Description:
Alpha-1 receptor binding studies were performed according to the methods described by Greengrass and Bremner (Eur. J. Pharmacol., 55:323-326, 1979) o...
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.930nM
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in CHO-K1 cell membrane after 60 mins by liquid scintillation countin...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 1.10nM
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Target
Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.26nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.30nM
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.30nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.39nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cells
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.40nM
Assay Description:
Binding affinity towards rat 5-hydroxytryptamine 7 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.40nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.40nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.5nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.58nM
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.60nM
Assay Description:
Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 7
(Mus musculus (Mouse))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.60nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.60nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.60nM
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 7
(Mus musculus (Mouse))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.60nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.70nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.70nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.70nM
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Target
Alpha-2C adrenergic receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.80nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Ability to displace [3H]-spiperone from D2 dopamine receptor isolated from the striata of male Wistar rats
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.90nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2nM
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.10nM
Assay Description:
Affinity for Dopamine receptor D2
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.20nM
Assay Description:
Binding affinity to human cloned dopamine D2 receptor
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Copy BDB DOI
Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.30nM
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.30nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.30nM
Assay Description:
In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.40nM
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Copy BDB DOI
Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.5nM
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.60nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.60nM
Assay Description:
Binding affinity towards human histamine H1 receptor
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 2.70nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 2.70nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.70nM
Assay Description:
Displacement of [3H]methylspiperone from human low affinity Dopamine D2S receptor by competition binding assay
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.70nM
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 2.80nM
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.80nM
Assay Description:
Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.80nM
Assay Description:
The binding affinity was measured on dopamine receptor D2 in rat brain tissue
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Target
Alpha-2C adrenergic receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3nM
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3nM
Assay Description:
The binding affinity was measured on adrenergic alpha-1 receptor in rat brain tissue
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3nM
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3nM
Assay Description:
Affinity for alpha-1 adrenergic receptor
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.10nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.10nM
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.10nM
Assay Description:
Compound was evaluated for its binding affinity with Dopamine receptor D2 using membranes prepared from rat striatum
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.10nM
Assay Description:
Binding affinity for dopamine receptor D2 determined using [3H]-spiperone
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.10nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in rat brain
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Target
Alpha-1B adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.16nM
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Inhibition of [3H]-rauwolscine binding to Alpha-2C adrenergic receptor
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Displacement of [3H]prazosin from rat cerebral cortex alpha1 adrenergic receptor measured after 60 mins by liquid scintillation counting method
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity to alpha1 adrenoceptor (unknown origin)
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.30nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.30nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.30nM
Assay Description:
Binding affinity towards human Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.55nM
Assay Description:
5-HT2A:(1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.60nM
Assay Description:
Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatum homogenates after 60 mins by liquid scintillation counting
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.60nM
Assay Description:
Antagonist activity at D2 receptor (unknown origin)
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [3H]-NPA from rat brain Dopamine receptor D2
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting method
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum homogenates after 30 mins by liquid scintillation counting
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum incubated for 30 mins by liquid scintillation counting analysi...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.77nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.80nM
Assay Description:
Binding affinity to dopamine D2 receptor (unknown origin)
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 3.80nM
Assay Description:
Binding affinity to D2 receptor (unknown origin)
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.80nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.90nM
Assay Description:
Binding affinity to dopamine D2 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.90nM
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.30nM
Assay Description:
Inhibition of [3H]-5-HT binding to human 5-hydroxytryptamine 7 receptor
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Target
D(2) dopamine receptor
(GUINEA PIG)
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.30nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.5nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.70nM
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.01nM
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.01nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.10nM
Assay Description:
Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.20nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.90nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.90nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.90nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.17nM
Assay Description:
Displacement of [3H]spiperone from human cloned dopamine D2 receptor
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.20nM
Assay Description:
Binding affinity measured at the Dopamine receptor D4 by the inhibition of [3H]-spiperone binding to human recombinant CHO cells using unlabeled halo...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.20nM
Assay Description:
Displacement of [3H]spiperone from human D2 receptor
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.20nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.30nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cells
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.40nM
Assay Description:
Inhibition of [3H]-spiperone binding to human Dopamine receptor D2
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.40nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.40nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 2C receptor
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.5nM
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.60nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.65nM
Assay Description:
Inhibitory constant against dopamine D2 receptor using 0.2 nM [3H]-spiperone
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.70nM
Assay Description:
Binding affinity to dopamine D3 receptor (unknown origin)
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.70nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.70nM
Assay Description:
Displacement of [3H]7OH-DPAT from dopamine D3 receptor (unknown origin) expressed in Sf9 cells by scintillation spectrometry
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 6.70nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7nM
Assay Description:
Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cells
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7nM
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D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
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Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7nM
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5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
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Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7nM
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7.40nM
Assay Description:
Displacement of [3H]mesulergine human cloned serotonin 5HT2C receptor
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7.40nM
Assay Description:
Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7.41nM
Assay Description:
Displacement of [3H]mesulergine from human 5HT2C receptor
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7.5nM
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Target
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Prestwick Chemical
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Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7.5nM
Assay Description:
Binding affinity towards human alpha-2 adrenergic receptor
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Target
D(4) dopamine receptor
(RAT)
University of Reading
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i
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Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7.5nM
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Alpha-2C adrenergic receptor
(RAT)
H. Lundbeck
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7.5nM
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 7.90nM
Assay Description:
Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 7.90nM
Assay Description:
Displacement of [3H]RX 821002 from adrenergic alpha-2 receptor in rat cerebral cortex
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 8nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 8.10nM
Assay Description:
In vitro ability to displace [3H]spiperone binding from dopamine receptor D2 in rat striatal membrane.
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Target
Alpha-2B adrenergic receptor
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 8.5nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 8.5nM
Assay Description:
Binding affinity to human cloned dopamine D4 receptor
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 9nM
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Case Western Reserve University
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 9.10nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 9.60nM
Assay Description:
Binding affinity to human cloned dopamine D3 receptor
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 9.80nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 10nM
Assay Description:
Binding affinity to human cloned 5HT2C receptor
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibition of [3H]-rauwolscine binding to Alpha-2A adrenergic receptor
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 10nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 11.6nM
Assay Description:
D2:Procedures(1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were m...
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 12nM
Assay Description:
Inhibition of [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptor
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 12nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 12.8nM
Assay Description:
5-HT7: (1) The prepared membrane was applied with buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed into a 100 ml container...
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 13nM
Assay Description:
Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cells
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 13nM
Assay Description:
Binding assays were carried out on rat recombinant D3 receptors (Perkin-Elmer, Cat. No. 6110139) expressed in Sf9 cells using [3H]spiperone (0.44-1.4...
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 13nM
Assay Description:
D2 receptor binding was determined as described by Creese et al. (Eur. J. Pharmacol., 60:55-66, 1979) on rat brain striatal membrane preparation usin...
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 13nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 13nM
Assay Description:
Binding affinity towards human Dopamine receptor D3
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 13nM
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 13nM
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 13nM
Assay Description:
Binding affinity measured at the Alpha-1A adrenergic receptor by the inhibition of [3H]-prazosin binding to rat cortex using unlabeled WB-4101 for no...
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Target
D(3) dopamine receptor
(Homo sapiens)
Huazhong University Of Science And Technology
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14nM
Assay Description:
Binding affinity to dopamine D3 receptor (unknown origin)
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Target
Histone H1.0
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14nM
Assay Description:
Binding affinity towards human dopamine receptor D3
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 14nM
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 14.1nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 15nM
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Target
Alpha-1A adrenergic receptor
(PIG)
Uppsala University
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 15.8nM
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Northeastern University
WIPO
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
Assay Description:
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...
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Copy BDB DOI
Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
Assay Description:
Inhibition of [125I]-iodosulpride binding to human Dopamine receptor D3
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
Assay Description:
Binding affinity towards human dopamine receptor D4
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Copy BDB DOI
Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
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Copy BDB DOI
Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
Assay Description:
Binding affinity towards human dopamine-4.2 receptor
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Copy BDB DOI
Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16nM
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Copy BDB DOI
Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 16.2nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D3 receptor
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Target
D(4) dopamine receptor
(RAT)
University of Reading
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 16.6nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 18nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 18nM
Assay Description:
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 19nM
Assay Description:
Binding affinity to human cloned histamine H1 receptor
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 19nM
Assay Description:
Binding affinity measured at the Dopamine receptor D2 by the inhibition of [3H]-methylspiperone binding to rat striatum using unlabeled haloperidol f...
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Target
BDBP50000595
(Homo sapiens)
Northeastern University
WIPO
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 19nM
Assay Description:
The affinity of ligands was determined via radioligand binding techniques using human recombinant receptors expressed in mammalian clonal cells. Deta...
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 20nM
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 20nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 20nM
Assay Description:
Binding affinity to H1 histamine receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Northeastern University
WIPO
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 20nM
Assay Description:
Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cells
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 1 receptor
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
Assay Description:
Binding affinity against dopamine receptor D1
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
Assay Description:
Binding affinity to 5-HT2C receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 21nM
Assay Description:
Displacement of [3H]mesulergine from rat cerebral cortex 5HT2C receptor measured after 15 mins by liquid scintillation counting method
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 22nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum after 60 mins by liquid scintillation counting analysis
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 22nM
Assay Description:
Affinity for Dopamine receptor D1
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 22nM
Assay Description:
Binding affinity to alpha1 adrenergic receptor (unknown origin)
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 23nM
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 23nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenate after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 24nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 24.5nM
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Target
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat))
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 25nM
Assay Description:
Binding affinity measured at the Alpha-2 adrenergic receptor by the inhibition of [3H]-clonidine binding to rat cortex using unlabeled NAbitartrate f...
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 26nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 27nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 27nM
Assay Description:
Displacement of [3H]mesulergine from 5-HT2C receptor in Sprague-Dawley rat cerebral cortex incubated for 15 mins in presence of spiperone by liquid s...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 27nM
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 28nM
Assay Description:
Binding affinity to alpha2 adrenergic receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 28nM
Assay Description:
Displacement of [3H]-mesulergine from serotonin 5-HT2C receptor in rat brain cerebral cortex homogenates incubated for 15 mins by liquid scintillatio...
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Northeastern University
WIPO
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 29.2nM
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 30nM
Assay Description:
Displacement of [3H]mesulergine from 5-HT2C receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 31nM
Assay Description:
Binding affinity measured at the Dopamine receptor D3 by the inhibition of [3H]-YM-09151-2 binding to human recombinant CCL 1.3 cells using unlabeled...
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 31.6nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 32nM
Assay Description:
Binding affinity to 5HT2C receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 32nM
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 32nM
Assay Description:
Displacement of [3H] 7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle homogenates after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 32nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 32.4nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 33nM
Assay Description:
Binding affinity to histamine H1 receptor (unknown origin)
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 33nM
Assay Description:
Inhibition of [3H]-pyrilamine binding to human Histamine H1 receptor
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]pyrilamine from guinea pig cerebellum histamine H1 receptor measured after 60 mins by liquid scintillation counting method
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 35nM
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Target
D(2) dopamine receptor
(GUINEA PIG)
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 37nM
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 38nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates after 60 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 39nM
Assay Description:
Binding affinity to 5HT2C receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 43nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in guinea pig cerebellum incubated for 60 mins by liquid scintillation counting analysis
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 44nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 44nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
University of Toronto
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 45nM
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 46nM
Assay Description:
Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation countin...
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Target
5-hydroxytryptamine receptor 2C
(PIG)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 48nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 49nM
Assay Description:
Binding affinity to H1 receptor (unknown origin)
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 50nM
Assay Description:
Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Solvay Pharma
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 55nM
Assay Description:
Displacement of [3H]-prazosin from alpha-1 adrenergic receptor in rat cerebral cortex homogenates incubated for 60 mins by liquid scintillation count...
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Target
5-hydroxytryptamine 1D receptor
(Bos taurus (Bovine))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 60nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 63nM
Assay Description:
Binding affinity towards human serotonin 5-hydroxytryptamine 2C receptor
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 63nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Target
5-hydroxytryptamine receptor 2C
(PIG)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 63nM
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 64nM
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 75nM
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Target
Histamine H1 receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 88nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 88nM
Assay Description:
Binding affinity towards human H1 receptor
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 91nM
Assay Description:
In vitro ability to displace [3H]mesulergine binding from 5-hydroxytryptamine 2C receptor from bovine choroid plexus.
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Target
5-hydroxytryptamine 1D receptor
(Bos taurus (Bovine))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 100nM
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Target
Alpha-2B adrenergic receptor
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 108nM
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Northeastern University
WIPO
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 115nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 130nM
Assay Description:
Ability to displace [3H]-8-OH-DPAT from serotonergic 5-hydroxytryptamine 1A receptor
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Target
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 140nM
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 147nM
Assay Description:
Inhibition of [3H]-SCH-23,390 binding to rat Dopamine receptor D1
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 148nM
Assay Description:
Displacement of [3H]SCH23390 from human dopamine D1 receptor
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Mayo Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 151nM
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Target
Histamine H1 receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 155nM
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 167nM
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Target
Histamine H1 receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 169nM
Assay Description:
Histamine H1: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were ...
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 171nM
Assay Description:
5-HT1A: (1) The prepared membrane was applied with appropriate amount of buffer, and homogenizer was used for evenly dispersing. 15 tubes were mixed ...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 182nM
Assay Description:
Binding affinity to 5-HT1A receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 182nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from serotonin 5-HT1A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation counting
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 182nM
Assay Description:
Displacement of [3H](+)8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 30 mins by liquid scintillation counting method
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 182nM
Assay Description:
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analy...
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 190nM
Assay Description:
Displacement of [3H]8OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus by scintillation spectrometry
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 190nM
Assay Description:
Binding affinity to 5HT1A receptor (unknown origin)
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 190nM
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5-hydroxytryptamine receptor 2B
(RAT)
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 203nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 210nM
Assay Description:
Binding affinity to human cloned 5HT1A receptor
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 211nM
Assay Description:
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in rat cerebral cortex homogenates after 60 mins by liquid scintillation counting
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5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 224nM
Assay Description:
Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells
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5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 250nM
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 251nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 251nM
Assay Description:
Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]-SCH-23,390 binding to rat striatum using unlabeled apomorphine for no...
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 253nM
Assay Description:
Compound was evaluated for its binding affinity with 5-hydroxytryptamine 1A receptor using membranes prepared from rat cerebral cortex
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 253nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligand
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 271nM
Assay Description:
Binding affinity to 5HT1A receptor (unknown origin)
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5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 339nM
Assay Description:
The binding affinity was measured on serotonin 5-hydroxytryptamine 1 receptor in rat brain tissue
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 417nM
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Target
5-hydroxytryptamine receptor 6
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 420nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 420nM
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Target
5-hydroxytryptamine receptor 6
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 420nM
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Target
5-hydroxytryptamine receptor 6
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 425nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 428nM
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Target
5-hydroxytryptamine receptor 6
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 430nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 490nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 491nM
Assay Description:
Binding affinity measured at the 5-hydroxytryptamine 1A receptor by the inhibition of [3H]-8-OH-DPAT binding to rat cortex using unlabeled buspirone ...
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 523nM
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Copy BDB DOI
Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 550nM
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Target
D(1B) dopamine receptor
(Homo sapiens (Human))
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 563nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 580nM
Assay Description:
Binding affinity to human cloned dopamine D1 receptor
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Copy BDB DOI
Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 620nM
Assay Description:
Binding affinity towards human Dopamine receptor D1
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Copy BDB DOI
Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 620nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 720nM
Assay Description:
The compound was tested binding affinity against 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand at 10e-6 M.
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 920nM
Assay Description:
Binding affinity to human ERG expressed in HEK293 cells by whole cell patch clamp method
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Target
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Ki: 950nM
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Target
Gastrin/cholecystokinin type B receptor
(RAT)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Beta-arrestin-1
(RABBIT)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Norepinephrine transporter
(RAT)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Neurotensin
(GUINEA PIG)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Delta-type opioid receptor
(MOUSE)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.00E+3nM
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Target
Kappa-type opioid receptor
(Cavia porcellus (domestic guinea pig))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Cholecystokinin
(GUINEA PIG)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
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Copy BDB DOI
Target
Thromboxane A2 receptor
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Protachykinin-1
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Huazhong University Of Science And Technology
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.11E+3nM
Assay Description:
Binding affinity to histamine H3 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.11E+3nM
Assay Description:
Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
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Target
5-hydroxytryptamine receptor 6
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.12E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.17E+3nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human 5-HT1AR expressed in HEK293 cell membranes after 1 hr by microbeta counting method
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 1.19E+3nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.19E+3nM
Assay Description:
Binding affinity to 5HT6 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.24E+3nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.26E+3nM
Assay Description:
Displacement of [3H]-lysergic acid diethylamide from human serotonin 5-HT6 receptor expressed in CHO cell membranes incubated for 30 mins by liquid s...
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.26E+3nM
Assay Description:
Displacement of [3H]lysergic acid diethylamide from human recombinant 5-HT6 receptor expressed in CHO cell membranes for 30 mins by liquid scintillat...
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Target
5-hydroxytryptamine receptor 1E
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.32E+3nM
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.33E+3nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.33E+3nM
Assay Description:
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor stably expressed in CHO cell membranes measured after 30 mins by ...
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.33E+3nM
Assay Description:
Binding affinity to 5-HT6 receptor (unknown origin)
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
Binding affinity to human SERT
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.00E+3nM
Assay Description:
Binding affinity to human cloned 5HT6 receptor
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40E+3nM
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40E+3nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 2.72E+3nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 2.80E+3nM
Assay Description:
Binding affinity to human cloned muscarinic M1 receptor
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.90E+3nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.70E+3nM
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Target
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 3.86E+3nM
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.00E+3nM
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 4.30E+3nM
Assay Description:
Binding affinity measured at the sigma receptor by the inhibition of [3H]-3-PPP binding to guinea pig cerebellum using unlabeled 3-PPP for nonspecifi...
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 5.00E+3nM
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: >5.00E+3nM
Assay Description:
Binding affinity towards human muscarinic receptor
More data for this Ligand-Target Pair
Target Info
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NCI pathway
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 5.00E+3nM
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(RAT)
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 5.00E+3nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 5.00E+3nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: >5.00E+3nM
Assay Description:
Binding affinity towards human M1 receptor.
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Target
Muscarinic acetylcholine receptor M2
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.00E+3nM
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.00E+3nM
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Target
Transporter
(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: >5.45E+3nM
Assay Description:
Inhibition of [3H]-nisoxetine binding to rat Norepinephrine transpoter
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
Centro De InvestigacióN Grupo Ferrer
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
Ki: 2.20E+4nM
Assay Description:
Binding affinity measured at the Beta-1 adrenergic receptor by the inhibition of [3H]-DHA binding to rat cortex using unlabeled isoprenalin for nonsp...
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Target
Transporter
(Rattus norvegicus (rat))
Florida A&M University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Binding affinity to rat NET
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 0.708nM
Assay Description:
Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...
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Target Info
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 0.720nM
Assay Description:
Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...
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Target Info
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 0.760nM
Assay Description:
Inhibition of [3H]ketanserin binding to dopamine 5-hydroxytryptamine 2 receptor
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.40nM
Assay Description:
Inhibition of [3H]-ketanserin binding to rat frontal cortex membrane 5-hydroxytryptamine 2A receptor
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Antagonist activity at 5-HT2C receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 2.60nM
Assay Description:
In vitro affinity towards 5-hydroxytryptamine 2A receptor using [3H]-spiroperidol as radioligand in cortex
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 3.60nM
Assay Description:
The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...
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Copy BDB DOI
Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 3.60nM
Assay Description:
The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 4nM
Assay Description:
Compound was tested for the inhibition of [3H]-spiperone binding to dopamine receptor D2
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 4.67nM
Assay Description:
The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 4.70nM
Assay Description:
Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 5nM
Assay Description:
Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 7nM
Assay Description:
Antagonistic activity at 5-HT2c receptor (unknown origin) after 10 mins by FLIPR assay
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 7nM
Assay Description:
Antagonistic activity at 5-HT2c receptor (unknown origin) after 10 mins by FLIPR assay
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 7.10nM
Assay Description:
Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assay
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 10nM
Assay Description:
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 10nM
Assay Description:
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 10.4nM
Assay Description:
The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10.4nM
Assay Description:
The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 11nM
Assay Description:
Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 11nM
Assay Description:
Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Intra-Cellular Therapies
US Patent
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 11nM
Assay Description:
Antagonist activity at alpha-1a adrenergic receptor (unknown origin)
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 13.3nM
Assay Description:
The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...
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Target
D(2) dopamine receptor
(Mus musculus (Mouse))
Glaxo Wellcome
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 23nM
Assay Description:
Inhibition of mouse Dopamine receptor D2
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 27nM
Assay Description:
Inhibition of [3H]-methylspiperone binding to rat striatal membrane Dopamine receptor D2
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 30nM
Assay Description:
Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissue
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Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 37nM
Assay Description:
In vitro affinity towards D2 receptor using [3H]-spiroperidol as radioligand in striatum
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 37nM
Assay Description:
Binding affinity towards Dopamine receptor D2 was determined in rat striatum using [3H]- spiperone as radioligand
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 38nM
Assay Description:
Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.
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Target
Histamine H1 receptor
(RAT)
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 80nM
Assay Description:
Displacement of [3H]mepyramine from H1R in rat brain
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 148nM
Assay Description:
Inhibition of human ERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 148nM
Assay Description:
Inhibition of human ERG channel
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of hERG K channel
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 151nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 151nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 162nM
Assay Description:
Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 162nM
Assay Description:
Inhibition of human ERG in MCF7 cells
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 163nM
Assay Description:
K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 167nM
Assay Description:
Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp method
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 167nM
Assay Description:
Inhibition of human ERG expressed in HEK293 cells at -50 mV holding potential by patch clamp assay
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 167nM
Assay Description:
Inhibition of human ERG by automated patch method relative to control
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 260nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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5-hydroxytryptamine receptor 1A
(Mus musculus (Mouse))
Glaxo Wellcome
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 430nM
Assay Description:
Inhibitory activity against serotonin 5-hydroxytryptamine 1A receptor from mice.
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 454nM
Assay Description:
Antagonist activity at H1 receptor (unknown origin)
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 454nM
Assay Description:
Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 454nM
Assay Description:
Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 454nM
Assay Description:
Antagonistic activity at histamine 1 receptor (unknown origin) after 10 mins by FLIPR assay
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 820nM
Assay Description:
Affinity for 5-hydroxytryptamine 1A receptor labeled with [3H]8-OH-DPAT radioligand in hippocampus tissue
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
Prestwick Chemical
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 868nM
Assay Description:
Antagonistic activity at histamine1 receptor (unknown origin) after 10 mins by FLIPR assay
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 950nM
Assay Description:
In vitro affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in hippocampus
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 950nM
Assay Description:
Binding affinity towards serotonin 5-HT1A receptor was determined in rat hippocampus using [3H]8-OH-DPAT as ligand
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.07E+3nM
Assay Description:
Inhibition of human ERG after 10 mins
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.33E+3nM
Assay Description:
Inhibition of human ERG by auomated patch clamp assay
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.33E+3nM
Assay Description:
Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISA
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Aventis Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Copy SMILES
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Affinity Data
IC50: 1.33E+3nM
Assay Description:
Inhibition of human ERG
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.60E+3nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Eli Lilly
Curated by
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i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Antagonist activity at muscarinic M3 receptor (unknown origin)
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: <1.03E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Solute carrier family 22 member 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.10E+4nM
Assay Description:
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S
(Homo sapiens (Human))
Chantest
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 3.42E+4nM
Assay Description:
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
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Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 7.30E+4nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 7.30E+4nM
Assay Description:
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
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D(2) dopamine receptor
(Homo sapiens (Human))
Acadia Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
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Database
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Antagonist activity at M3 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
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Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.02E+5nM
Assay Description:
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
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Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.16E+5nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 1.25E+5nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Multidrug and toxin extrusion protein 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
IC50: 2.91E+5nM
Assay Description:
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Albumin
(Rattus norvegicus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
Kd: 4.38E+4nM
Assay Description:
Binding affinity to Wistar rat serum albumin
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5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
EC50: >1.00E+5nM
Assay Description:
The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay
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Glycine receptor subunit alpha-1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
ChEMBL
Ligand
BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
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Affinity Data
EC50: 320nM
Assay Description:
Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...
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