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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  1.40nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  1.5nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  8nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  17nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  18nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  57nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  67nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  67nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  82nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  160nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  160nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  170nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  210nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  381nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  381nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent