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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
NACHT, LRR and PYD domains-containing protein 3
(Human)
Cadila Healthcare
Curated by
ChEMBL
Ligand
BDBM50538421
(CHEMBL4649141 | US11236045, Example 30)
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Affinity Data
IC50: 23nM
Assay Description:
Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Uromodulin
(Human)
Cadila Healthcare
US Patent
Ligand
BDBM50538421
(CHEMBL4649141 | US11236045, Example 30)
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Affinity Data
IC50: 28nM
Assay Description:
THP1 (Tamm-Horsfall Protein 1) monocytes were differentiated with PMA (Phorbol 12-myristate 13-acetate) (100 ng/ml) and incubated at 37° C. for 20 h ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
NACHT, LRR and PYD domains-containing protein 3
(Human)
Cadila Healthcare
Curated by
ChEMBL
Ligand
BDBM50538421
(CHEMBL4649141 | US11236045, Example 30)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in TNF alpha level preincubated for 1 hr followed by...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI