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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 31 hits in this display   

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused Nurr1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bovine)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  2.00E+5nMAssay Description:Compound was tested for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >4.00E+5nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-beta(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  2.50E+4nMAssay Description:Agonist activity at human RXRbeta transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  1.61E+4nMAssay Description:Agonist activity at human RXRalpha transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  4.01E+4nMAssay Description:Agonist activity at human RXRgamma transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKd:  1.00E+6nMAssay Description:Binding affinity to 15N-labelled His6-tagged SARS-CoV Mac3 (527 to 652 residue) expressed in Escherichia coli Rosetta assessed as chemical shift pert...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetComplement C5(Human)
Indian Institute of Technology Bhubaneswar

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKd:  640nMAssay Description:Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed