Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  13nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated PBMC (unknown origin) assessed as reduction in IL-1beta release pretreated for 30 mins followed by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  34nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human THP1-ASC-GFP cells assessed as reduction in speck positive cells measured after 30 mins in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Nodthera

Curated by ChEMBL
LigandPNGBDBM50601245(CHEMBL5196139)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human whole blood assessed as reduction in IL-1beta release pretreated for 30 mins followed by ATP...More data for this Ligand-Target Pair
In DepthDetails PubMed