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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetLiver carboxylesterase 1(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CES2A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University

LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50:  1.60E+4nMpH: 7.2 T: 2°CAssay Description:The activity of the compounds is determined by measuring the inhibitory effect of the compounds in the direction of glycogen synthesis, the conversio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University

LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
The Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University

LigandPNGBDBM23209((1R,2R,5S,8R,9R,10R,13R,14R,17S,18R,19R)-17-hydrox...)
Affinity DataIC50:  1.03E+5nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed