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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  56nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  131nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50: >1.88E+4nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50: >1.88E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50: >1.88E+4nMAssay Description:Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50: >1.88E+4nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed