Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetNeurogenic locus notch homolog protein 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541992(CHEMBL4644426)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541992(CHEMBL4644426)
Affinity DataIC50:  2nMAssay Description:Modulation of human gamma secretase expressed in HEK293 cells assessed as reduction in total amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541992(CHEMBL4644426)
Affinity DataIC50:  4nMAssay Description:Modulation of gamma secretase in human H4 cells overexpressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in free...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541992(CHEMBL4644426)
Affinity DataIC50:  4nMAssay Description:Modulation of human gamma secretase expressed in HEK293 cells assessed as reduction in free amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50541992(CHEMBL4644426)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed