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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM297396
(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
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Affinity Data
EC50: 15nM
Assay Description:
Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM297396
(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 15nM
Assay Description:
Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM297396
(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 30nM
Assay Description:
Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential incubated ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI