Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297396(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Affinity DataEC50:  15nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator [1-507,509-1480](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297396(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Affinity DataEC50:  15nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM297396(3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carbo...)
Affinity DataEC50:  30nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential incubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed