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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
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Affinity Data
IC50: 0.360nM
Assay Description:
Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.360nM
Assay Description:
Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
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Affinity Data
IC50: 360nM
Assay Description:
Inhibition of recombinant human MMP14 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrs
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
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Affinity Data
IC50: 370nM
Assay Description:
Inhibition of recombinant human MMP13 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
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Affinity Data
IC50: 530nM
Assay Description:
Inhibition of recombinant human MMP2 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50337723
(CHEMBL1683450 | N-((2S,4S)-1-(4-(4-chloro-2-methyl...)
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Copy InChI
Affinity Data
IC50: >8.50E+3nM
Assay Description:
Inhibition of recombinant human MMP1 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI