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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  7.30nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of recombinant human MMP14 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of recombinant human MMP13 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50: >10nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  980nMAssay Description:Inhibition of recombinant human MMP1 assessed as substrate cleavage by measuring increase in fluorescence after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50337728(CHEMBL1683445 | N-((2S,4S)-1-(4-(4-fluorophenyl)pi...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed