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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHepcidin(Homo sapiens)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  28nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  39nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  52nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1 [147-509](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: <100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [147-509](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: <100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [147-509](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: <100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  300nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  300nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  538nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  1.25E+3nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent