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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
16
hits in this display
Target
Neprilysin
(Homo sapiens (Human))
University Of Paris
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
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Target
Neprilysin
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 1.70nM
Assay Description:
50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.
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Target
Aminopeptidase N
(Sus scrofa (Pig))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 3.80nM
Assay Description:
Inhibitory activity against aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 10nM
Assay Description:
Inhibitory activity against LTA 4 hydrolase in aminopeptidase assay
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Target Info
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 18nM
Assay Description:
Inhibitory activity against LTA 4 hydrolase in epoxide hydrolase assay
More data for this Ligand-Target Pair
Target Info
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Target
Aminopeptidase N
(Homo sapiens (Human))
University Of Paris
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
Ki: 7.00E+3nM
Assay Description:
Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)
More data for this Ligand-Target Pair
Target Info
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NCI pathway
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Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibitory activity against Leu-enkeph of Neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
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Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
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Target
Thermolysin
(Bacillus thermoproteolyticus)
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)
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Target Info
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibitory activity was determined against Leukotriene A4 hydrolase
More data for this Ligand-Target Pair
Target Info
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibitory activity against recombinant human Leukotriene A4 hydrolase
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8nM
Assay Description:
Inhibitory activity against big ET-1 of Neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
IC50: 8nM
Assay Description:
Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1
More data for this Ligand-Target Pair
Target Info
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Target
Neprilysin
(Oryctolagus cuniculus (rabbit))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 46nM
Assay Description:
Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)
More data for this Ligand-Target Pair
Target Info
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Target
Angiotensin-converting enzyme
(Oryctolagus cuniculus)
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibitory activity against rabbit lung angiotensin-converting enzyme (ACE)
More data for this Ligand-Target Pair
Target Info
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50105264
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Copy SMILES
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibitory activity was determined for LTB4 production in human whole blood.
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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Ligand Info
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ChEBI
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In Depth
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PubMed
PDB
3D Structure (crystal)
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