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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Michigan State University

LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataKi:  6.40E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human cathepsin B (332 residues) expressed in CHO cells using Z-FR-AMC as substrate preincubated for 20 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1/Calpain-2 catalytic subunit(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50:  600nMAssay Description:Inhibition of calpain (unknown origin) using calpain substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50:  5.09E+3nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease ATG4B(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of caspase3 (unknown origin) using Ac-DMQD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-9(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase9 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ACE (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP9 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of tryptase beta2 (unknown origin) using Z-GPR-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase2 (unknown origin) using ICH-1 as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cathepsin G (unknown origin) using Suc-AAPF-pNA as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of neutrophil elastase (unknown origin) using MeOSu-AAPV-AMC as substrate preincubated for 20 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S proteasome (unknown origin) using suc-LLVY-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase8 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human cathepsin D (400 residues) expressed in CHO cells using 5-FAM/QXL 520 FRET peptide as substrate preincubated for 20 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ECE1 (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase7 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP1 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Roche Pharma Research And Early Development

Curated by ChEMBL
LigandPNGBDBM50536839(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP3 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed