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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target
Replicase polyprotein 1ab
(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Michigan State University
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
Ki: 6.40E+4nM
Assay Description:
This is a review article. Please point to the original journal.
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Target
Cathepsin B
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: 300nM
Assay Description:
Inhibition of recombinant human cathepsin B (332 residues) expressed in CHO cells using Z-FR-AMC as substrate preincubated for 20 mins followed by su...
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Target
Calpain-1/Calpain-2 catalytic subunit
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: 600nM
Assay Description:
Inhibition of calpain (unknown origin) using calpain substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader a...
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antibodypedia
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Target
Cysteine protease ATG4B
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: 5.09E+3nM
Assay Description:
Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assay
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Target
Cysteine protease ATG4B
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: 1.50E+4nM
Assay Description:
Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...
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Target Info
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MMDB
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Target
Caspase-3
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: 4.35E+4nM
Assay Description:
Inhibition of caspase3 (unknown origin) using Ac-DMQD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
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Target Info
PDB
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KEGG
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Target
Caspase-9
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of caspase9 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of ACE (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pla...
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Target Info
PDB
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of MMP9 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
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Target
Tryptase beta-2
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of tryptase beta2 (unknown origin) using Z-GPR-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...
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Target Info
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Target
Caspase-2
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of caspase2 (unknown origin) using ICH-1 as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader...
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Target Info
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Target
Cathepsin G
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of cathepsin G (unknown origin) using Suc-AAPF-pNA as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...
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Target Info
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Target
Neutrophil elastase
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of neutrophil elastase (unknown origin) using MeOSu-AAPV-AMC as substrate preincubated for 20 mins followed by substrate addition by fluor...
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Target
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of 20S proteasome (unknown origin) using suc-LLVY-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
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Target
Caspase-8
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of caspase8 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Cathepsin D
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of recombinant human cathepsin D (400 residues) expressed in CHO cells using 5-FAM/QXL 520 FRET peptide as substrate preincubated for 20 m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of ECE1 (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
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Target
Caspase-7
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of caspase7 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Interstitial collagenase
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of MMP1 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Stromelysin-1
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM50536839
(CHEMBL2402203 | acs.jmedchem.1c00409_ST.724)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of MMP3 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC cid
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In Depth
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PubMed
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