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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
Ki: 2.63E+4nM
Assay Description:
Binding affinity towards human serum albumin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Article
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Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
TBA
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: 374nM
Assay Description:
Inhibition of Homo sapiens (human) aldose reductase
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Target Info
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: 8.80E+3nM
Assay Description:
Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis
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Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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Article
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
Guangzhou Institutes Of Biomedicine And Health
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
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Ligand Info
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: 6.37E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target Info
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Target
Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: 8.75E+4nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Target Info
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target Info
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Article
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.26E+5nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Xiamen University
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
Kd: >1.00E+5nM
Assay Description:
Binding affinity to GAL4-DBD-fused PPARgamma ligand binding domain (unknown origin) expressed in HEK293T cells by spectra-fluorophotometry analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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GoogleScholar
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In Depth
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Article
PubMed
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Target
Complement C5
(Homo sapiens)
Indian Institute Of Technology Bhubaneswar
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
Kd: 570nM
Assay Description:
Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis
More data for this Ligand-Target Pair
Target Info
PDB
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In Depth
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Article
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Xiamen University
Curated by
ChEMBL
Ligand
BDBM50103504
(CHEBI:9352 | Clinoril | Sulindac)
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Affinity Data
EC50: 2.27E+4nM
Assay Description:
Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI