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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  1.60nMAssay Description:BTK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.BTK enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  2nMAssay Description:TEC enzyme (Millipore #14-801M), is diluted to 2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  2.10nMAssay Description:TXK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.TXK enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  2.90nMAssay Description:BMX enzyme (Millipore #14-499M), is diluted to 0.5 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  287nMAssay Description:ITK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.ITK enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM515333(US11110088, Compound Table 1.7)
Affinity DataIC50:  549nMAssay Description:EGFR enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.EGFR enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent