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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  200nM ΔG°:  -37.9kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  1.30E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  2.00E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  5.70E+3nM ΔG°:  -29.6kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  3.30E+4nM ΔG°:  -25.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed