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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Affinity Data
IC50: 5nM
Assay Description:
In vitro inhibition of tumor necrosis factor-alpha converting enzyme
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Affinity Data
IC50: 185nM
Assay Description:
In vitro inhibition of Matrix metalloprotein 13
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Affinity Data
IC50: 753nM
Assay Description:
In vitro inhibition of Matrix metalloprotein-9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Copy InChI
Affinity Data
IC50: 759nM
Assay Description:
Inhibition of MMP9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
UniversitÀ
Curated by
ChEMBL
Ligand
BDBM50131516
(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
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Copy InChI
Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI