SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display

Homeodomain-interacting protein kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

IC50: 119nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Homeodomain-interacting protein kinase 1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 248nMAssay Description:Inhibition of human recombinant HIPK1 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Homeodomain-interacting protein kinase 3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 476nMAssay Description:Inhibition of human recombinant HIPK3 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 946nMAssay Description:Inhibition of human recombinant CLK1 using ERMRPRKRQGSVR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 1.43E+3nMAssay Description:Inhibition of human recombinant CLK2 using YRRAAVPPSPSLSR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK4(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 1.47E+3nMAssay Description:Inhibition of human recombinant CLK4 using YRRAAVPPSPSLS substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK1A using RRRFRPASPLRGPP substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK1B using RRRFRPASPLRGPP substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant DYRK2 using casein substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >3.00E+3nMAssay Description:Inhibition of human full length recombinant CLK3 using ERMRPRKRQGSVR substrate by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 1.80E+4nMAssay Description:Inhibition of CLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 4.30E+4nMAssay Description:Inhibition of CLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 4.30E+4nMAssay Description:Inhibition of DYRK1A (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK4(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: 4.60E+4nMAssay Description:Inhibition of CLK4 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of MLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of DYRK1B (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of DYRK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of MLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of MLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-dependent kinase-like 3(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of CDKL3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK1(Homo sapiens (Human))
Masaryk University

Curated by ChEMBL

BDBM50563533(CHEMBL4777288)

IC50: >5.00E+4nMAssay Description:Inhibition of CLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Filter my 21 hits

Targets 14▿
- Dual specificity protein kinase CLK1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Dual specificity protein kinase CLK4 2
- Dual specificity protein kinase CLK3 2
- Dual specificity protein kinase CLK2 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 2
- Mitogen-activated protein kinase kinase kinase 9 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Cyclin-dependent kinase-like 3 1
- Mitogen-activated protein kinase kinase kinase 10 1
- Mitogen-activated protein kinase kinase kinase 11 1
- Homeodomain-interacting protein kinase 3 1
Publications 1▿
- Eur J Med Chem 215: (2021) 21
Institutions 1▿
- Masaryk University 21
Affinity: 1.2E+2 to 5.0E+4 nM▿
- IC50 21
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0