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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
41
hits in this display
Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: 0.794nM
Assay Description:
Inhibition of LCK
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Copy SMILES
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Affinity Data
Ki: 60nM
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: 500nM
Assay Description:
Inhibitory activity against Src in cell free assay
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: 500nM
Assay Description:
Binding affinity to human recombinant Abl by cell free assay
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Copy SMILES
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Affinity Data
Ki: 500nM
Assay Description:
Inhibition of human recombinant Src
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase CSK
(Homo sapiens (Human))
University of Dundee
Curated by
PDSP K
i
Database
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: 730nM
More data for this Ligand-Target Pair
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Target
Casein kinase I isoform delta
(Rattus norvegicus (rat))
University of Dundee
Curated by
PDSP K
i
Database
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: 1.29E+3nM
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Ki: <1.00E+4nM
Assay Description:
Inhibition of EGFR
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of Src (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assay
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Ankara University
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 0.5nM
T: 2°C
Assay Description:
Kinase activity (Src-family kinases, Hck, Lyn, Fyn, and c-Src) and the effect of the molecules were determined by ProFluor Src-Family Kinase Assay Ki...
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Copy SMILES
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of LCK (unknown origin)
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Copy SMILES
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of p56lck autophosphorylation
Checked by Author
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Target
Tyrosine-protein kinase HCK
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of Hck
Checked by Author
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Ankara University
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of FYN (unknown origin)
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Ankara University
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 6nM
Assay Description:
The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Ankara University
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 10nM
Assay Description:
Inhibition of FYN (unknown origin) by cell culture based assay
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Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 19nM
Assay Description:
Inhibition of RIP2 in the presence of 100uM ATP
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Target
Proto-oncogene tyrosine-protein kinase LCK
(Mus musculus)
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 31nM
Assay Description:
Inhibition of Lck in the presence of 50uM ATP
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Target
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 36nM
Assay Description:
Inhibition of Src in the presence of 50uM ATP
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 36.6nM
Assay Description:
Inhibition of human tyrosine kinases.
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 36.6nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
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Target
Casein kinase I isoform delta
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 41nM
Assay Description:
Inhibition of CK1delta in the presence of 20uM ATP
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition cSRC
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 172nM
Assay Description:
Inhibition of human tyrosine kinases.
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Target
Tyrosine-protein kinase ABL1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 172nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 480nM
Assay Description:
Inhibition of EGFR
Checked by Author
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 500nM
Assay Description:
Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 3...
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Target
Tyrosine-protein kinase CSK
(Homo sapiens (Human))
University of Dundee
Curated by
PDSP K
i
Database
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 500nM
pH: 7.5 T: 2°C
Assay Description:
The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)...
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of GST-fussed c-SRC after 30 mins
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of GST-tagged c-Src preincubated for 30 mins measured after 60 mins
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 2.80E+3nM
Assay Description:
Inhibition of c-Src after 60 mins
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Korea Institute Of Science & Technology (Kist School)
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 4.23E+3nM
Assay Description:
Inhibition of p38 alpha (unknown origin) using Ser/Thr 15 as substrate incubated for 1 hr in presence of ATP by Z'-Lyte assay
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Target
Ephrin type-B receptor 2
(Homo sapiens (Human))
Protana
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: 5.20E+4nM
Assay Description:
Inhibition of EPH receptor B2 using ELISA
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Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: >5.00E+7nM
Assay Description:
Inhibition of JAK2
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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DrugBank
antibodypedia
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Target
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
IC50: >1.00E+8nM
Assay Description:
Inhibition of ZAP70
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Kd: 296nM
Assay Description:
Binding affinity to chicken 6-His tagged c-Src expressed in Escherichia coli Bl21 (DE3) assessed as dissociation constant
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Target Info
PDB
MMDB
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KEGG
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Target
Ephrin type-A receptor 3
(Homo sapiens (Human))
Cha University
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Kd: 2.00E+5nM
Assay Description:
Inhibition of EPHA3 (unknown origin) assessed as dissociation constant by ELISA-like binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
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B.MOAD
antibodypedia
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Target
Ephrin type-B receptor 2
(Homo sapiens (Human))
Protana
Curated by
ChEMBL
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
Kd: 3.65E+4nM
Assay Description:
Equilibrium binding constant for EPH receptor B2
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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Target
Vacuolar aminopeptidase 1
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
EC50: 4.82E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
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Target
60S ribosomal protein L19-A
(Saccharomyces cerevisiae)
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM50142887
(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
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Affinity Data
EC50: 1.29E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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