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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
58
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Ki: 0.0541nM
Assay Description:
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARalpha LBD by TR-FRET assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Binding affinity to PPARalpha (unknown origin) by TR-FRET assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Ki: 7nM
Assay Description:
Binding affinity to PPARalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysis
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
Ki: 10nM
Assay Description:
Binding affinity to PPARalpha (unknown origin) by TR-FRET based LanthaScreen competitive binding assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
IC50: 0.460nM
Assay Description:
Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay
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Target
Huntingtin
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
IC50: 4.40E+3nM
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Target
Bile acid receptor
(Homo sapiens (Human))
City Of Hope National Medical Center
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
IC50: 4.91E+3nM
Assay Description:
Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay
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Target
WD repeat-containing protein 48
(Homo sapiens (Human))
University Of Connecticut Health Center
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay
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Target
Ubiquitin carboxyl-terminal hydrolase 1
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of USP1 (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 0.890nM
Assay Description:
Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 15nM
Assay Description:
Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactam...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 14nM
Assay Description:
Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 7.10nM
Assay Description:
Agonist activity at PPAR-alpha (unknown origin) expressed in HEK293 cells by TR-FRET assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Kd: 32nM
Assay Description:
Binding affinity to human PPAR-alpha LBD assessed as recruitment of fluorescein-labeled coactivator peptide by surface plasmon resonance method
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 230nM
Assay Description:
Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 250nM
Assay Description:
Agonist activity at wild-type human PPARalpha Thr279Ala mutant expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 6.5nM
Assay Description:
Agonist activity at human PPARalpha transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 200nM
Assay Description:
Transactivation of human PPARalpha expressed in African green monkey COS7 cells incubated overnight by dual-glo luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 200nM
Assay Description:
Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 230nM
Assay Description:
Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Lucif...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 200nM
Assay Description:
Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based trans...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 200nM
Assay Description:
Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at GAL4-tagged human PPARalpha ligand binding domain chimeric receptor expressed in HEK293 cells after 24 hrs by luciferase reporter...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
Kd: 1nM
Assay Description:
Binding affinity to human PPARalpha (unknown origin) by competitive TR-FRET assay
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Helmholtz Centre For Infection Research
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Kd: 180nM
Assay Description:
Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 200nM
Assay Description:
Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 200nM
Assay Description:
Transactivation of GAL4-fused human PPARalpha ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1.80nM
Assay Description:
Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 0.600nM
Assay Description:
Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 400nM
Assay Description:
Agonist activity at human PPARalpha LBD by cell based luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Copy SMILES
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Affinity Data
EC50: 50nM
Assay Description:
Agonist activity at human PPARalpha
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 200nM
Assay Description:
Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 26nM
Assay Description:
Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 7nM
Assay Description:
Agonist activity at human GAL4 fused PPARalpha-LBD expressed in human HepG2 cells after 18 hrs by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 6nM
Assay Description:
Agonist activity at PPARalpha (unknown origin)
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 5nM
Assay Description:
Agonist activity at PPARalpha (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay
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Target
Pre-mRNA-processing factor 19
(Saccharomyces cerevisiae S288c)
Polymer Functionalization Group (Ictp, Csic)
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 178nM
Assay Description:
Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at N-terminal Gal4 fused human PPARalpha LBD transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 3nM
Assay Description:
Agonist activity at human PPAR-alpha
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 5.40nM
Assay Description:
Agonist activity at GAL4-tagged PPARalpha-LBD (unknown origin) expressed in HEK293 cells assessed as induction of receptor transactivation incubated ...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 9nM
Assay Description:
Agonist activity at human PPARalpha transfected in human HepG2 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 2.08E+3nM
Assay Description:
Agonist activity at human Gal4 fused PPARalpha LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1.40nM
Assay Description:
Agonist activity at PPARalpha (unknown origin)
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 20nM
Assay Description:
Partial agonist activity at PPARalpha (unknown origin) assessed as increase in PRIP/RAP250 coactivator peptide requirement by Lanthascreen TR-FRET as...
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 9nM
Assay Description:
Agonist activity at pBIND tagged human PPARalpha expressed in human HepG2 cells incubated for 18 hrs by dual luciferase reporter assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 6.5nM
Assay Description:
Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1nM
Assay Description:
Agonist activity at human PPAR-alpha expressed in CHO-K1 cells by PathHunter assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 7nM
Assay Description:
Agonist activity at human PPARalpha measured by dual luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor delta
(Mus musculus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 2.90E+3nM
Assay Description:
Activation of murine PPAR delta ligand binding domain
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 6nM
Assay Description:
In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Helmholtz Centre For Infection Research
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1.10E+3nM
Assay Description:
In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain
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Target
Peroxisome proliferator-activated receptor gamma
(Mus musculus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1.30E+3nM
Assay Description:
Activation of murine PPAR gamma ligand binding domain
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 6.20E+3nM
Assay Description:
In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain
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Target
Peroxisome proliferator-activated receptor alpha
(Mus musculus)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1nM
Assay Description:
Activation of murine PPAR alpha ligand binding domain
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Kd: 9.64E+4nM
Assay Description:
Binding affinity to PPARalpha LBD (unknown origin) by surface plasmon resonance assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 1.86E+4nM
Assay Description:
Agonist activity at PPARalpha LBD (unknown origin) assessed as induction of PGC1alpha co-activator activity by TR-FRET analysis
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Sahmyook University
Curated by
ChEMBL
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
EC50: 5.70nM
Assay Description:
Agonist activity at human PPARalpha incubated for 22 to 24 hrs by luciferase assay
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Target
Fatty acid-binding protein, intestinal
(Homo sapiens (Human))
Monash University
Ligand
BDBM50099491
(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
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Affinity Data
Kd: 1.30E+3nM
pH: 8.0 T: 2°C
Assay Description:
ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...
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