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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50303763
((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
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Affinity Data
IC50: 1.20E+5nM
Assay Description:
Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50303763
((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.20E+5nM
Assay Description:
Inhibition of FTO (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
PubMed
Copy BDB DOI
Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50303763
((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
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Copy InChI
Affinity Data
IC50: >4.00E+5nM
Assay Description:
Inhibition of human PHD2 at 293K temperature by solvent relaxation technique
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50303763
((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 3.30E+4nM
Assay Description:
Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Egl nine homolog 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50303763
((R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 3.30E+4nM
Assay Description:
Binding affinity to human PHD2 by nondenaturing ESI-MS
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI