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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Macrophage metalloelastase
(Homo sapiens (Human))
Kobe Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM28476
((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
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Affinity Data
IC50: 6.20nM
Assay Description:
Inhibition of recombinant human MMP12 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorescence spectrometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Macrophage metalloelastase
(Homo sapiens (Human))
Kobe Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM28476
((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
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Copy InChI
Affinity Data
IC50: 8.10nM
pH: 7.5 T: 2°C
Assay Description:
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Kobe Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM28476
((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
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Copy InChI
Affinity Data
IC50: 65nM
Assay Description:
Inhibition of recombinant human MMP13 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorescence spectrometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Kobe Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM28476
((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 200nM
Assay Description:
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI