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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Kobe Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of recombinant human MMP12 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorescence spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Kobe Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  8.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Kobe Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  65nMAssay Description:Inhibition of recombinant human MMP13 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorescence spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Kobe Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  200nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed