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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
16
hits in this display
Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 0.130nM
Assay Description:
Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligand
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 0.130nM
Assay Description:
Inhibition of [125I]VCAM-Ig binding to Alpha-4 beta-1 (VLA-4) of Jurkat cells
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of Integrin alpha-4-beta-1-mediated adhesion in human jurkat cells
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Target
Integrin alpha-L/beta-2
(Homo sapiens (Human))
University Of Bologna
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 0.840nM
Assay Description:
Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of integrin alpha4-beta1 binding to VCAM-Ig
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of integrin alpha4-beta1 adhesion to Jurkat cells
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Target Info
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 4.80nM
Assay Description:
Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 7.60nM
Assay Description:
Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1
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Target Info
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Copy InChI
Affinity Data
IC50: 7.60nM
Assay Description:
Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
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Target
Integrin alpha-4/beta-1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 8.60nM
Assay Description:
Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Integrin alpha-4/beta-7
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 433nM
Assay Description:
Inhibition of [125I]VCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells
More data for this Ligand-Target Pair
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Target
Integrin alpha-4/beta-7
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 862nM
Assay Description:
Inhibition of [125I]MAdCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells
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Target
Integrin alpha-4/beta-7
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of integrin alpha4-beta7 adhesion to JY cells
More data for this Ligand-Target Pair
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Target
Integrin alpha-IIb/beta-3
(Homo sapiens (Human))
Biogen
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of integrin alphaIIb-beta3 adhesion to human citreated platelets
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Target Info
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Target
Integrin alpha-5/beta-1
(Homo sapiens (Human))
Biogen
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of integrin alpha5-beta1 adhesion to K562 cells
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Target
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human))
Biogen
Curated by
ChEMBL
Ligand
BDBM50074661
((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of ICAM-1 transfected CHO cell adhesion to integrin alphaL-beta2 of human JY cells
More data for this Ligand-Target Pair
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