Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetMacrophage metalloelastase(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  6nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluor...More data for this Ligand-Target Pair

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TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  7.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair

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TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  33nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetStromelysin-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  90nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetMatrilysin(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  210nMAssay Description:Inhibition of MMP7 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  480nMAssay Description:Inhibition of ADAM9 (unknown origin)More data for this Ligand-Target Pair

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Target72 kDa type IV collagenase(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetCollagenase 3(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of ADAM10 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetNeutrophil collagenase(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of MMP14 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetInterstitial collagenase(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of recombinant human MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

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TargetInterstitial collagenase(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50:  4.63E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 ??L containing 1% DMSO. Recombinant Human catalytic domains of...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Nestl�

Curated by ChEMBL

LigandBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells assessed as reduction in tail current amplitude by patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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