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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
24
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 0.0900nM
Assay Description:
Inhibition of human matrix metalloprotease-2
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Target
Macrophage metalloelastase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 0.800nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 1.60nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetry
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 1.60nM
Assay Description:
Inhibition of human matrix metalloprotease-8
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Target
Collagenase 3
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 4.10nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP13 after 4 hrs by fluorimetry
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Target Info
PDB
MMDB
NCI pathway
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 6.70nM
Assay Description:
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 6.70nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 6.70nM
Assay Description:
Inhibition of human matrix metalloprotease-9
More data for this Ligand-Target Pair
Target Info
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 9.80nM
Assay Description:
Inhibition of human matrix metalloprotease-14
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Copy SMILES
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Affinity Data
IC50: 9.80nM
Assay Description:
Inhibition of human recombinant pro-MMP14 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
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Target
Stromelysin-1
(Homo sapiens (Human))
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Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of trypsin activated human pro-MMP3 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Stromelysin-1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of human matrix metalloprotease-3
More data for this Ligand-Target Pair
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Target
Matrix metalloproteinase-16
(Homo sapiens (Human))
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Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 51nM
Assay Description:
Inhibition of human recombinant pro-MMP16 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Interstitial collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 147nM
Assay Description:
Inhibition of human matrix metalloprotease-1
More data for this Ligand-Target Pair
Target Info
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Target
Interstitial collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 490nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP1 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
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Target
Matrilysin
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of human matrix metalloprotease-7
More data for this Ligand-Target Pair
Target Info
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Target
Matrilysin
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Copy SMILES
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of human matrix metalloprotease-7
More data for this Ligand-Target Pair
Target Info
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 1.40E+4nM
Assay Description:
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry
More data for this Ligand-Target Pair
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Target
Elastase
(Pseudomonas aeruginosa)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 5.70E+4nM
Assay Description:
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...
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Target
Thermolysin
(Bacillus thermoproteolyticus)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 4.16E+5nM
Assay Description:
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...
More data for this Ligand-Target Pair
Target Info
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Target
Elastase
(Pseudomonas aeruginosa)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 7.98E+5nM
Assay Description:
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...
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Target
Thermolysin
(Bacillus thermoproteolyticus)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50161330
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
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Affinity Data
IC50: 8.00E+5nM
Assay Description:
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...
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