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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Interleukin-1 receptor-associated kinase 3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of kinase tracer 236 binding to recombinant human full-length GST-tagged IRAK3 expressed in insect cells by Lanthascreen Eu kinase binding...
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Target Info
PDB
NCI pathway
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Target
Cyclin-C/Cyclin-dependent kinase 19
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 16nM
Assay Description:
Inhibition of CDK11/cyclin C (unknown origin)
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Target
Cyclin-C
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 36nM
Assay Description:
Inhibition of CDK8/cyclin C (unknown origin)
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Target
NT-3 growth factor receptor
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of NTRK3 (unknown origin)
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Target Info
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MMDB
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KEGG
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Target
Serine/threonine-protein kinase haspin
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of GSG2 (unknown origin)
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Target Info
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MMDB
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Target
Protein cereblon
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 460nM
Assay Description:
Inhibition of CRBN (unknown origin)
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Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...
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Target Info
PDB
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Target
Interleukin-1 receptor-associated kinase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
IC50: 2.30E+3nM
Assay Description:
Inhibition of recombinant human N-terminal GST-tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using 5-FAM-KKKVSRSGLYRS...
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Target Info
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Target
Cyclin-dependent kinase 19
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
Kd: >3.00E+4nM
Assay Description:
Displacement of polymer supported probe 25 binding to CDK11 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
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Target
Cyclin-dependent kinase 8
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
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Affinity Data
Kd: 1.40E+3nM
Assay Description:
Displacement of polymer supported probe 25 binding to CDK8 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
In Depth
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Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
Copy SMILES
Copy InChI
Affinity Data
Kd: 3.60E+3nM
Assay Description:
Displacement of polymer supported probe 25 binding to IRAK4 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
Copy SMILES
Copy InChI
Affinity Data
Kd: 34nM
Assay Description:
Displacement of polymer supported probe 25 binding to IRAK3 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase haspin
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
Copy SMILES
Copy InChI
Affinity Data
Kd: 780nM
Assay Description:
Displacement of polymer supported probe 25 binding to GSG2 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interleukin-1 receptor-associated kinase 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50560888
(CHEMBL4749646)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.80E+3nM
Assay Description:
Displacement of polymer supported probe 25 binding to IRAK1 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI