Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 30 hits in this display   

TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  24.7nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  56.7nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  57nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  7.29E+3nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:pA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular veinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)
Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
In DepthDetails US Patent