Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 9 hits in this display
ADAMTS5(Rattus norvegicus (Rat))Galapagos
US Patent
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
IC50: 23nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
IC50: 433nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
IC50: >2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
BDBM379669(US9926281, Compound 193 | US9926281, Compound 412)
IC50: >2.00E+4nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair