Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...)
Affinity DataEC50:  4nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...)
Affinity DataEC50:  0.620nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...)
Affinity DataEC50:  0.420nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandPNGBDBM301429(4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...)
Affinity DataEC50:  12.5nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent