Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 22 hits in this display   

TargetPlasma kallikrein(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Rattus norvegicus)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Mus musculus)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  45nMAssay Description:Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein(Sus scrofa)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  300nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  500nMAssay Description:Inhibition of human factor 11a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  800nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK5 (67 to 293 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-13(Homo sapiens)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  820nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK14 (19 to 248 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-2(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK2 (1 to 261 residues) expressed in mouse NS0 cells using fluorogenic PFR-AMC peptide as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged matriptase catalytic domain (596 to 855 residues) expressed in Escherichia coli using fluoroge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged factor Xa (24 to 488 residues) expressed in baculovirus derived insect sf21 cells using fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human plasmin using fluorogenic D-AFK-ANSNH-iC4H9.2HBr peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human alpha thrombin using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human Cathepsin-GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGranzyme B(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human Granzyme B (21 to 247 residues) using fluorogenic Ac-IEPD-pNA peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged complement component C1s (1 to 688 residues) expressed in mouse NS0 cells using fluorogenic Z-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human activated protein C by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-6(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-12(Homo sapiens)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed