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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
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Affinity Data
Ki: 6.10nM
Assay Description:
Time dependant inhibition of recombinant N-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli expression system assessed as inhi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <3nM
Assay Description:
Inhibition of recombinant N-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli expression system using ART-K(Me1)-QTARKSTGGKAPRK...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific demethylase 2A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
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Copy InChI
Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of LSD2 (unknown origin) by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
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Copy InChI
Affinity Data
IC50: >8.00E+4nM
Assay Description:
Inhibition of MAO-B (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >8.00E+4nM
Assay Description:
Inhibition of MAO-A (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Constellation Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM424912
(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2nM
Assay Description:
Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI